Enflurane (Ethrane, compound 347) in man.

Coagulation-fibrinolysis system in man during Ethrane anaesthesia and surgery.

The coagulation-fibrinolysis system was studied during Ethrane anaesthesia and gynaecological operations in 20 patients. No particular change was noted in the platelet counts, which remained within the normal range. In the coagulation system, no appreciable change was observed except for the partial thromboplastin time (P.T.T.) which was significantly short-ended, both 30 minutes after the star...

Ventilation and chemoreflexes during enflurane sedation and anaesthesia in man.

Enflurane sedation and anaesthesia in healthy fit subjects reduced ventilation and the response to carbon dioxide, hypoxaemia and a low dose of doxapram, all in a dose-related fashion. Comparing the three chemoreflexes tested, the response to hypoxaemia and doxapram were the more profoundly impaired; they were nearly totally abolished by anaesthesia. These effects of enflurane on chemoreflex ac...

Influence of halothane and enflurane on respiratory airflow resistance and specific conductance in anaesthetized man.

We have developed a method for the measurement of respiratory resistance and specific airways conductance (s.Gaw) using the forced airflow oscillation method, and have used it to study the effects of halothane and enflurane on airway mechanics in anaesthetized patients. Resistance (i?ra) was determined over a range of lung volumes and s.Gaw was obtained by computer-aided analysis of the hyperbo...

Bez nazwy-347

Brit. J. Anaesth. (1972), 44,1234 ELECTROGRAPHIC ALTERATIONS INDUCED IN LIMBIC AND SENSORY SYSTEMS DURING INDUCTION OF ANAESTHESIA WITH HALOTHANE, METHOXYFLURANE, DIETHYL ETHER, AND ENFLURANE (ETHRANE)*

In the present study of the effects of four volatile agents, diethyl ether, methoxyflurane, halothane and enflurane on the brain, a definite spontaneous activity pattern of various subcortical structures indicating onset of analgesia could be established only for enflurane. It consisted of high voltage spiking activity separated by periods of burst suppression of various durations. Brief period...